Dylan Pen, Julia Shanks, Carolyn Barrett, Yonis Abukar, Julian Paton and Rohit Ramchandra published a paper entitled, ‘Aortic body chemoreceptors regulate coronary blood flow in conscious control and hypertensive sheep’.
This is an excellent paper in a very good journal and the results come from a very difficult research model. Please join me in particularly congratulating PhD student, Dylan Pen, and co-first author research fellow, Julia Shanks on a great paper.
Peripheral arterial chemoreceptors monitor the chemical composition of arterial blood and include both the carotid and aortic bodies (ABs). While the role of the carotid bodies has been extensively studied, the physiological role of the ABs remains relatively under-studied, and its role in hypertension is unexplored. We hypothesized that activation of the ABs would increase coronary blood flow in the normotensive state and that this would be mediated by the parasympathetic nerves to the heart. In addition, we determined whether the coronary blood flow response to stimulation of the ABs was altered in an ovine model of renovascular hypertension.
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