Jason H. Yeung, Beatriz Calvo-Flores Guzman, Thulani H. Palpagama, Jayarjun Ethiraj, Ying Zhai, Warren P. Tate, Katie Peppercorn, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky have published a paper in Journal of Neurochemistry with an editorial highlight entitled, ‘Amyloid‐beta1–42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus’.
The first author of the article is Jason Yeung. He is a 5th year medical student. He has completed a Bachelor of Medical Science (Honours) degree at the Centre for Brain Research, Department of Anatomy and Medical Imaging. He was supervised by Dr Andrea Kwakowsky and co-supervised by Distinguished Professor Sir Richard Faull.
Alzheimer’s disease (AD) is the leading type of dementia worldwide. With an increasing burden of an aging population coupled with the lack of any foreseeable cure, AD warrants the current intense research effort on the toxic effects of an increased concentration of beta‐amyloid (Aβ) in the brain.
Their findings indicate that Aβ1-42 induces region and layer specific expression changes in the hippocampus of the glutamatergic receptors and transporters, suggesting complex and spatial vulnerability of this pathway during development of AD neuropathology. These changes have the ability to alter normal glutamatergic signalling and could contribute to AD pathology. A better understanding of glutamatergic receptor and transporter changes in AD could lead to new pharmacological approaches to target specific components of the signalling pathway.
Editorial highlight for this article