Nishi Karunasinghe, Stefan Ambs, Alice Wang, Wei Tang, Shuotun Zhu, Tiffany, HDorsey, Megan Goudie, Jonathan G. Masters and Lynnette R. Ferguson published a paper entitled ‘Influence of lifestyle and genetic variants in the aldo-keto reductase 1C3 rs12529 polymorphism in high-risk prostate cancer detection variability assessed between US and New Zealand cohorts
A team from our faculty, Auckland hospital and that of the National Cancer Institute USA recently compared a NZ prostate cancer cohort with that of a cohort from USA. Their prostate cancer detection related information shows that age, PSA and Gleason sum at cancer diagnosis is higher in the NZ cohort. The cumulative high-risk prostate cancer detection variation with increasing PSA class intervals show that high-risk cancers are detected at late PSA intervals in NZ cohort compared to the US cohort. This gets aggravated among patients that had a tobacco smoking past and carrying certain genotypes.
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